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KMID : 0366220090440030182
Korean Journal of Hematology
2009 Volume.44 No. 3 p.182 ~ p.187
The Association between Multiple Myeloma and Ankylosing Spondylitis: A Report of Two Cases
Moon Hyung-Il

Chang Hyoung-Jin
Kim Ji-Eun
Ko Hoon-Young
Ann Seo-Hee
Min Chang- Ki
Abstract
Multiple myeloma is a malignant disease of plasma cells, whereas ankylosing spondylitis is a chronic inflammatory disease of axial joints. The relationship between the two diseases is uncertain, but chronic inflammation could trigger multiple myeloma. The authors report the cases of two ankylosing spondylitis patients with a disease duration of more than 20 years, that subsequently developed IgA kappa and IgG lambda chain myeloma, respectively, and discuss the possible pathogenetic relationship between these diseases.
KEYWORD
Multiple myeloma, Monoclonal gammopathy of undetermined significance, Ankylosing spondylitis, Inflammation, Tumor
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